Hormone Replacement Therapy

Hormone Replacement Therapy
Personalized, bioidentical hormone therapy for men and women… led by a dual board-certified endocrinologist who tests before treating.
4.8/5 from 180+ Google reviews
3,000+ patients treated
Dual board-certified endocrinologist
In-person in OKC + telehealth in 46 states
Hormone replacement therapy (HRT) at Modern Endocrine in Oklahoma City restores balance to hormones like estrogen, progesterone, and testosterone using bioidentical, custom-compounded treatments.
Led by dual board-certified endocrinologist Dr. Cassie Smith, our team tests before we treat… running 30+ biomarkers to find the root of your symptoms instead of masking them. We offer pellets, creams, patches, and injections for both men and women.
Most patients begin feeling relief from fatigue, brain fog, low libido, and night sweats within two to six weeks.
We don’t guess… we test.


What is bioidentical hormone replacement therapy?
Bioidentical hormone replacement therapy uses hormones that are structurally identical to the ones your body makes. At Modern Endocrine, they’re custom-compounded and dosed to match your specific levels and delivered through pellets, creams, patches, or injections. The goal is to treat the source of your imbalance… not just quiet the symptoms.
When hormones drift out of balance, the effects show up everywhere: your energy, sleep, mood, weight, and sex drive. Standard care often stops at “your labs are normal.” We look at optimal ranges, not just normal ones, and we connect your hormone levels to the rest of your body… gut, thyroid, and metabolism… so the plan actually fixes what’s wrong.
We help you find the hormone delivery method that best supports your body, with treatments designed for steady, consistent balance over time — and many patients notice meaningful improvement within two to four weeks of starting.
What symptoms does hormone replacement therapy help with?

HRT can relieve:
- Fatigue
- Brain Fog
- Night Sweats
- Hot Flashes
- Low Libido
- Mood Swings
- Poor Sleep
- Weight Gain
- Hair Thinning
- Joint pain &
- Vaginal Dryness.
These are common signs of imbalanced estrogen, progesterone, or testosterone… even when routine labs come back “normal.”
If several of these sound familiar, your hormones are worth a closer look.
HRT for Women
Bioidentical hormone therapy can support women through perimenopause, menopause, and beyond… using testosterone alone, testosterone with estrogen, or all three with progesterone, delivered as creams, patches, or pellets.
Progesterone is typically delivered as oral pills or rapid dissolving tablets.
- Hot flashes & night sweats
- Sleep trouble, fatigue, brain fog
- Low libido & vaginal dryness
- Mood swings, anxiety, irritability
- Weight gain, hair thinning, dry skin
HRT for Men
Bioidentical hormone therapy can help men feel like themselves again — whether symptoms came on with age or have been there for years.
Delivered as creams, pellets, or injections based on your labs.
- Low energy & needing more sleep
- Low muscle mass & more belly fat
- Low sex drive & erectile dysfunction
- Brain fog, irritability, low mood
- Weight gain, joint pain, dry skin
How do hormone pellets, creams, and injections compare?
All three deliver bioidentical hormones; they differ in how often you dose and how steady the release is. Pellets are placed under the skin and release hormones steadily for months. Creams are applied daily. Injections are given on a set schedule.
The right choice depends on your hormones, your labs, and your preference — and we’ll help you decide.
| Method | How You Take It | Best For |
|---|---|---|
| Placed under the skin; steady release over several months | Those seeking long-lasting, consistent hormone support with the least daily upkeep | |
| Applied to the skin daily after you shower | Those who want a customizable, non-invasive option with easy dose adjustments | |
| Given on a set schedule, often weekly | Men who prefer precise testosterone dosing and are comfortable with self-injection or in-office injections | |
| Worn on the skin and typically changed twice a week | Those who prefer steady hormone delivery in a simple, transdermal form |
We test, not guess
How does HRT work at Modern Endocrine?
We start by testing, not guessing. After a free discovery call, you’ll have an intake visit, complete lab work, and then sit down for a 60-minute lab review where Dr. Smith builds your personalized hormone plan. From there, we adjust and follow up so your levels stay where they should be.
Discovery Call
Free, no-pressure fit check
Intake Visit
In-person or telehealth
Lab Work
30+ biomarkers
Lab Review
60-min personalized plan
Ongoing Care
Adjust & recheck
How soon will you feel results from HRT?
Many patients notice changes within two to six weeks, with fuller results over two to three months as your levels stabilize.
The exact timeline depends on the imbalance and the delivery method
Here’s what patients typically report:
2–4 weeks
Brain fog and libido
4–6 weeks
Energy, sleep and mood
12–16 weeks
Body composition and weight
Why choose Modern Endocrine for HRT?
Modern Endocrine is the only functional health clinic in Oklahoma City led by a dual board-certified endocrinologist. We run 30+ biomarkers on every new patient, give you a full hour to review your results, and you see the same provider every visit.
We connect your hormones to your gut, thyroid, and metabolism… so you get answers, not just a prescription.
- Led by a dual board-certified endocrinologist
- 30+ biomarkers tested, not the usual 8–12
- A full 60 minutes to review your labs
- Same provider & health coach every visit
- Bioidentical, personalized hormone plans
- In person in OKC + telehealth in 46 states

what our patient say
How much does HRT cost, and do you take insurance?
Modern Endocrine is a cash-pay (self-pay) clinic, so your care plan is driven by your health… not by insurance rules. We accept HSA and FSA cards, major credit cards, and offer payment plans. The best place to start is a free discovery call, where we’ll explain exactly what your hormone program would include and cost.
Dr. Cassie Smith, MD
Dr. Cassie Smith is the founder of Modern Endocrine in Oklahoma City and is dual board-certified in endocrinology and internal medicine.
She completed her residency at the University of Missouri School of Medicine and her endocrinology fellowship at the OU Health Sciences Center and Harold Hamm Diabetes Center. She is certified in bioidentical hormone replacement therapy and serves on the medical faculty of Evexias Medical, training other providers in hormone and gut health.
Named a Top Doctor by 405 Magazine, she is the author of an Amazon best selling book, “Fix Your Gut, Fix Your Hormones” and host of the podcast “Hormones, Metabolism, and You.”

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Frequently asked questions
Bioidentical hormone replacement therapy uses hormones that are structurally identical to the ones your body makes. At Modern Endocrine, they’re custom-compounded and dosed to your levels and delivered as pellets, creams, patches, or injections to treat the source of your symptoms.
Adults dealing with fatigue, low libido, mood changes, poor sleep, stubborn weight gain, hot flashes, dry skin, muscle aches, or perimenopause and menopause symptoms — especially when standard labs look “normal” but you don’t feel right.
Yes, when it’s guided by a qualified medical provider with appropriate labs, screening, and follow-up. At Modern Endocrine, a dual board-certified endocrinologist oversees your testing and treatment.
In some cases, yes — hormone replacement therapy may still be an option after cancer. The right approach depends on the type of cancer you had, whether it was hormone-sensitive, your symptoms, your medical history, and your overall health.
At Modern Endocrine, we believe these decisions should never be one-size-fits-all. We take time to review your history in detail, help you understand the risks and benefits of treatment, and design a personalized plan that supports both symptom relief and long-term wellness.
Yes. Testosterone is a normal part of women’s hormone health, and low-dose bioidentical testosterone can help with energy, mood, muscle mass, and libido when prescribed and monitored by a qualified provider.
Many patients notice changes within two to six weeks, with fuller results over three to four months as hormone levels stabilize. The timeline depends on the imbalance and delivery method.
We offer bioidentical pellets, creams, patches, oral capsules and injections. The best option depends on your labs, your symptoms, which hormone(s) you are deficient in, and your preference, and we’ll help you choose.
Yes. Telehealth patients can be treated with hormone creams, patches, and injections. Modern Endocrine is licensed to provide telehealth in 46 states, with in-person care available in Oklahoma City.
Modern Endocrine is a cash-pay clinic, so your plan isn’t limited by insurance rules. We accept HSA/FSA cards, major credit cards, and payment plans. Start with a free discovery call to learn what your program would cost.
Most of the time, yes. HRT is often needed long term because your body is no longer making adequate hormone levels on its own. However, if we can lower inflammation, address underlying imbalances, and support your body’s natural hormone production, we will always do that. In some cases, this may allow us to reduce your dose over time. Ultimately, as long as you want the benefits of HRT, you will likely want to remain on treatment.
No. Birth control is not the same as hormone replacement therapy (HRT). Birth control typically contains synthetic hormones designed to prevent pregnancy, while HRT is used to help restore and optimize hormone levels in the body. Depending on your age, symptoms, and health goals, birth control can sometimes be more harmful than helpful. We will help you determine which option is safest and most appropriate for your body and your needs.
Ready to feel like yourself again?
Book your free discovery call and find out whether bioidentical hormone therapy is right for you. No pressure, no obligation… just answers.

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850 NW 58th Street, Oklahoma City, OK 73118
(405) 286-1571
Mon–Fri 8am–5pm
