Weight Loss

Medical Weight Loss
If you're doing everything right and still feel stuck, it's time to stop guessing.


Medical weight loss at Modern Endocrine in Oklahoma City goes beyond calories to address the hormonal and metabolic factors that can make weight loss feel impossible.
Led by dual board-certified endocrinologist Dr. Cassie Smith, our team tests before we treat… running 30+ biomarkers to find what’s actually driving your weight instead of guessing.
We don’t just hand you a meal plan… we look at how your whole body works together, paying special attention to insulin, thyroid, cortisol, sex hormones, and gut health, the systems that quietly control your metabolism.
Why can’t I lose weight, even when I’m doing the right things?
Often the problem isn’t effort… it’s biology. Insulin resistance, thyroid issues, high cortisol, shifting hormones in perimenopause, and gut imbalances can all make weight loss feel impossible, even when you’re eating well and exercising. Until those factors are properly tested and addressed, dieting harder usually doesn’t lead to lasting results. That’s why we start by identifying what’s driving stubborn weight.
Weight loss is complex, and there may be underlying factors affecting your progress that you don’t even realize are there. Instead of giving you another generic plan, we begin with lab testing to get a clearer picture of your hormones, metabolism, thyroid, and gut health. Once we understand what your body truly needs, we create a personalized plan that fits you and provide the accountability and support to help you achieve lasting results.
Our two-part approach to weight loss
We combine two things most programs treat separately: finding your root cause, and using GLP-1 medication the smart way.
Finding and fixing the root cause
We look at all the underlying hormonal and metabolic causes of weight gain, then build a plan for sustained results and better energy. Testing can include:
- Thyroid
- Insulin
- Blood Sugar
- Cortisol
- Sex hormones &
- Gut health…
the systems that control your metabolism. We treat what we find instead of telling you to simply eat less and move more.

Science-informed GLP-1 microdosing
GLP-1 medications can be a helpful tool for weight loss, but only if you’re the right candidate. When appropriate, we may use a personalized microdosing approach with smaller, carefully monitored doses tailored to your body, goals, and response. The goal is steady progress, fewer side effects, and better muscle protection with a strong focus on protein.
GLP-1s are never a stand-alone fix. They work best when paired with the habits that make results last: enough protein, strength training, quality sleep, daily sunlight, and regular movement.

What is GLP-1 microdosing?
GLP-1 microdosing means using a lower-than-standard dose under close medical supervision. It’s not right for everyone, but for the right patient, it can support sustainable weight loss with fewer side effects and better long-term consistency.
At Modern Endocrine, dosing is never one-size-fits-all. Your plan is guided by your labs, symptoms, goals, and progress, then adjusted case by case by our physician-led team.
Because the dose is lower and personalized, many patients tolerate treatment better and stay consistent… and consistency is what drives results. Microdosing isn’t a shortcut or a substitute for the fundamentals; it works alongside protein, strength training, sleep, and sunlight. Your provider monitors your progress and adjusts as you go.
Is this weight loss program right for you?
Is this weight loss program right for you?
This program is built for people who’ve tried and stalled. It may be a fit if you recognize yourself here:
- You eat well and exercise, but the weight won’t budge.
- Your labs were called “normal,” but you know something’s off.
- Weight crept up in perimenopause or menopause.
- You suspect insulin resistance, thyroid, or hormones are involved.
- You’ve lost weight before and regained it.
- You have gut symptoms like bloating, gas, and/or acid reflux with weight gain
- You want a doctor-led plan, not another fad diet.

What’s included in your weight loss plan?
Every plan is personalized, but most bring together four parts that work as one:
| What’s Included | What It Does | Why It Matters |
|---|---|---|
Root-cause lab testing | 30+ biomarkers across insulin, thyroid, cortisol, sex hormones, & gut health | Finds what’s actually stalling your weight loss |
GLP-1 microdosing | Smaller, physician-monitored doses that support steady loss with fewer side effects | Monitors your progress and helps you avoid the “one-size-fits-all” approach |
Nutrition & strength | Adequate protein, strength training, sleep, movement, and sunlight built into your routine | Protects muscle and makes results last |
Coaching & accountability | The same provider and health coach, following through with you over time | You’re not walking this journey alone |
Why choose Modern Endocrine for weight loss?
Modern Endocrine is the only functional medicine clinic in Oklahoma City led by a dual board-certified endocrinologist. We treat the cause of weight gain… hormones, metabolism, thyroid, and gut… not just the symptom. You get real testing, real time with your provider, and real accountability.
- Led by a dual board-certified endocrinologist — weight treated as a medical, hormonal issue
- 30+ biomarkers tested… not the usual 8–12
- GLP-1 microdosing done right — physician-monitored and muscle-protecting
- Same provider & health coach every visit — real follow-through
- Nutrition, strength, sleep, and stress management built into your plan
- In person in OKC + telehealth in 46 states


How much does HRT cost, and do you take insurance?
Modern Endocrine is a cash-pay (self-pay) clinic, so your care plan is driven by your health… not by insurance rules. We accept HSA and FSA cards, major credit cards, and offer payment plans. The best place to start is a free discovery call, where we’ll explain exactly what your hormone program would include and cost.


Dr. Cassie Smith, MD
Dr. Cassie Smith is the founder of Modern Endocrine in Oklahoma City and is dual board-certified in endocrinology and internal medicine.
She completed her residency at the University of Missouri Kansas City School of Medicine and her endocrinology fellowship at the OU Health Sciences Center and Harold Hamm Diabetes Center.
As an endocrinologist, she treats weight as a hormonal and metabolic issue… testing the systems that control metabolism and tailoring treatment, including GLP-1 therapy, to each patient. Named a Top Doctor by 405 Magazine, she is the author of an Amazon best-selling book, Fix Your Gut, Fix Your Hormones and host of the podcast “Hormones, Metabolism, and You.”
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Frequently asked questions
Medical weight loss is doctor-led and starts with lab testing to find the hormonal and metabolic causes of weight gain. Instead of a generic meal plan, you get a personalized plan… which may include GLP-1 microdosing, gut support, hormone optimization, nutrition, strength training, and coaching… with a provider tracking your progress and adjusting as your body responds.
Because weight loss is more complex than calories alone. If your hormones, metabolism, thyroid, stress response, sleep, or insulin levels are off, your body may fight you every step of the way … even when your effort is good and your labs look “normal.” . We look for the reasons your body is resisting weight loss instead of blaming you for it.
Yes. Hormones help regulate appetite, blood sugar, fat storage, energy, and metabolism. When they’re out of balance, weight loss can feel impossible even when you’re doing a lot of the right things.
It can. Thyroid issues may contribute to fatigue, slower metabolism, and difficulty losing weight. That’s why thyroid function should be evaluated in the bigger picture, not brushed off with a one-size-fits-all answer
It can. Poor gut health may affect inflammation, cravings, blood sugar balance, digestion, and how well your hormones function. If your gut is off, your weight-loss efforts may feel harder than they should.
Not every weight-gain problem is a willpower problem. If your gut, hormones, thyroid, blood sugar, stress response, or sleep are off, your body may be working against you. That’s why we don’t start with random labs. We start with the full picture. Depending on your symptoms, that may include testing for gut health, thyroid function, blood sugar and insulin patterns, cholesterol, liver markers, and other hormone imbalances like PCOS or cortisol issues. We also look at non-lab drivers that get missed, including medications, poor sleep, chronic stress, and sleep apnea.
The goal is simple: find out why your body is holding onto weight so your plan can actually work.
These medications can help reduce hunger, improve fullness, and support better blood sugar regulation. They are tools, not magic. The best results happen when medication is paired with a personalized plan that addresses nutrition, lifestyle, and root-cause issues.
GLP-1 microdosing means using a smaller, closely monitored dose of a GLP-1 medication than the standard regimen. The goal is steady weight loss with fewer side effects while helping you keep muscle. At Modern Endocrine, dosing is physician-guided and based on your labs.
GLP-1 medications are well studied, and any GLP-1 treatment should be prescribed and monitored by a qualified medical provider after an evaluation. It isn’t right for everyone, so we review your health history and labs before starting and follow you closely while you’re on it.
Muscle loss is a known risk with rapid weight loss, which is why our plans prioritize adequate protein, strength training, and a steady pace. Protecting muscle is a core goal of our microdosing approach.
Not necessarily. Some patients use GLP-1 support for a defined period while we address the root causes… insulin resistance, thyroid, hormones, and gut health… that make weight loss hard. As your metabolism improves, we may be able to lower your dose or transition you off, while you keep the habits that maintain your results. Your plan is reviewed regularly with your provider.
The most common side effects are usually digestive, such as nausea, constipation, diarrhea, or vomiting. Not everyone has the same experience, and side effects can often be reduced with the right dosing strategy, nutrition support, and close follow-up.
Results vary by person, your starting point, and what’s driving your weight. Our approach focuses on steady, sustainable fat loss while protecting muscle, rather than rapid crash dieting. We track your labs and progress the whole way.
Yes. Modern Endocrine is licensed to provide telehealth in 46 states, with in-person care available in Oklahoma City. Your provider will determine the right plan for you during your visits.
Modern Endocrine is a cash-pay clinic, so your plan isn’t limited by insurance rules. We accept HSA/FSA cards, major credit cards, and payment plans. Start with a free discovery call to learn what your program would cost.
Both. The same hidden factors… hormones, thyroid, insulin, and gut health… can make even a small amount of stubborn weight hard to lose. We tailor the plan to your goal, whether that’s a major change or the last stretch that won’t budge.
Ready to find out what’s really going on?
Book your free discovery call and let’s figure out what’s driving your weight… together. We’d be honored to support you on your health journey. No pressure, no obligation… just answers.

© 2026 Modern Endocrine, All Rights Reserved.
850 NW 58th Street, Oklahoma City, OK 73118
(405) 286-1571
Mon–Fri 8am–5pm
This page is for general education and is not medical advice.
GLP-1 treatment is prescribed only after evaluation and is not appropriate for everyone. Individual results vary.
